VEGF Inhibition and Renal Thrombotic Microangiopathy
نویسندگان
چکیده
منابع مشابه
Thrombotic Microangiopathy in Renal Allografts
The term “thrombotic microangiopathy” (TMA) encompasses non-inflammatory small vessel vasculopathies that are caused by severe endothelial and medial smooth muscle cell injury/necrosis. TMAs can be promoted by a variety of “toxic” stimuli ranging from malignant range hypertension, E. coli infections with bloody diarrhea, radiation, systemic diseases such as scleroderma to iatrogenic events such...
متن کاملThrombotic microangiopathy and associated renal disorders*
Thrombotic microangiopathy (TMA) is a pathological process involving thrombocytopenia, microangiopathic haemolytic anaemia and microvascular occlusion. TMA is common to haemolytic uraemic syndrome (HUS) associated with shiga toxin or invasive pneumococcal infection, atypical HUS (aHUS), thrombotic thrombocytopenic purpura (TTP) and other disorders including malignant hypertension. HUS complicat...
متن کاملProgressive bevacizumab-associated renal thrombotic microangiopathy*
Vascular endothelial growth factor (VEGF) is integral to the integrity of the glomerular filtration barrier. Bevacizumab is a humanized monoclonal antibody directed against VEGF with expanding clinical applications for metastatic solid tumours. We describe a case of a 61-year-old female with ovarian cancer and baseline chronic kidney disease who received three doses of bevacizumab and subsequen...
متن کاملCyclosporine-associated thrombotic microangiopathy in renal allografts.
BACKGROUND The association between cyclosporine (CsA) and thrombotic microangiopathy (TMA) in renal allografts is well documented. However, predisposing factors and therapy guidelines are not adequately characterized. METHODS We reviewed 188 patients with kidney or kidney-pancreas transplants who were treated between January 1994 and December 1996 with prednisone, CsA, or tacrolimus, and azat...
متن کاملRenal thrombotic microangiopathy induced by β-interferon
hematoma caused by insulin injections. Clin Nucl Med 1990; 15: 539–541 2. Yoshida T, Harayama T, Kusunoki C et al. A case of type 2 diabetes mellitus with a giant subcutaneous hematoma caused by rough insulin injection. J Japan Diab Soc 2008; 51: 929–932 3. Kahara T, Kawara S, Shimizu A et al. Subcutaneous hematoma due to frequent insulin injections in a single site. Intern Med 2004; 43: 148–14...
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ژورنال
عنوان ژورنال: New England Journal of Medicine
سال: 2008
ISSN: 0028-4793,1533-4406
DOI: 10.1056/nejmoa0707330